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The tammar wallaby major histocompatibility complex shows evidence of past genomic instability

Siddle, Hannah V; Deakin, Janine E; Coggill, Penny; Whilming, Laurens; Harrow, Jennifer; Kaufman, Jim; Beck, Stephan; Belov, Katherine

Description

BACKGROUND The major histocompatibility complex (MHC) is a group of genes with a variety of roles in the innate and adaptive immune responses. MHC genes form a genetically linked cluster in eutherian mammals, an organization that is thought to confer functional and evolutionary advantages to the immune system. The tammar wallaby (Macropus eugenii), an Australian marsupial, provides a unique model for understanding MHC gene evolution, as many of its antigen presenting genes are not linked to the...[Show more]

CollectionsANU Research Publications
Date published: 2011-08-19
Type: Journal article
URI: http://hdl.handle.net/1885/95566
Source: BMC Genomics
DOI: 10.1186/1471-2164-12-421

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