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Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

Ziolkowski, Andrew F; Popp, Sarah K; Freeman, Craig; Parish, Christopher; Simeonovic, Charmaine


The autoimmune type 1 diabetes (T1D) that arises spontaneously in NOD mice is considered to be a model of T1D in humans. It is characterized by the invasion of pancreatic islets by mononuclear cells (MNCs), which ultimately leads to destruction of insulin-producing β cells. Although T cell dependent, the molecular mechanisms triggering β cell death have not been fully elucidated. Here, we report that a glycosaminoglycan, heparan sulfate (HS), is expressed at extraordinarily high levels within...[Show more]

CollectionsANU Research Publications
Date published: 2012-12-19
Type: Journal article
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI46177


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