Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes
The autoimmune type 1 diabetes (T1D) that arises spontaneously in NOD mice is considered to be a model of T1D in humans. It is characterized by the invasion of pancreatic islets by mononuclear cells (MNCs), which ultimately leads to destruction of insulin-producing β cells. Although T cell dependent, the molecular mechanisms triggering β cell death have not been fully elucidated. Here, we report that a glycosaminoglycan, heparan sulfate (HS), is expressed at extraordinarily high levels within...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Clinical Investigation|
|01_Ziolkowski_Heparan_sulfate_and_heparanase_2012.pdf||Published Version||2.47 MB||Adobe PDF|
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