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Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

Parish, Ian A; Marshall, Heather D; Staron, Matthew M; Lang, Philipp A; Brüstle, Anne; Chen, Jonathan H; Cui, Weiguo; Tsui, Yao-Chen; Perry, Curtis; Laidlaw, Brian J; Ohashi, Pamela; Weaver, Casey T; Kaech, Susan M


During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the relevant cellular sources of IL-10, as well as the pathways responsible for IL-10 induction, remain unclear. In this study, we traced IL-10 production over the course of chronic lymphocytic...[Show more]

CollectionsANU Research Publications
Date published: 2014-07-08
Type: Journal article
Source: Journal of Clinical Investigation
DOI: 10.1172/JCI66108


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