LINE-1 Based Insertional Mutagenesis Screens to Identify Genes Involved in Embryonic Stem Cell Differentiation
Background: Knowledge of the intrinsic properties of embryonic stem cells is essential before the possibility of using these cells for therapeutic purposes becomes a reality. Insertional mutagenesis screens are widely used to identify genes sufficient to confer a particular phenotype; however, applications of such approaches are limited to mouse models. Thus, there is a need to develop a new DNA transposon system that allows gene discovery approaches in stem cells. Methods: This study was...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Stem Cell Research & Therapy|
|01_Hun Lee_LINE-1_Based_Insertional_2012.pdf||Published Version||1.68 MB||Adobe PDF|
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