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LINE-1 Based Insertional Mutagenesis Screens to Identify Genes Involved in Embryonic Stem Cell Differentiation

Lee, Sung-Hun; Rangasamy, Danny

Description

Background: Knowledge of the intrinsic properties of embryonic stem cells is essential before the possibility of using these cells for therapeutic purposes becomes a reality. Insertional mutagenesis screens are widely used to identify genes sufficient to confer a particular phenotype; however, applications of such approaches are limited to mouse models. Thus, there is a need to develop a new DNA transposon system that allows gene discovery approaches in stem cells. Methods: This study was...[Show more]

CollectionsANU Research Publications
Date published: 2012-03-14
Type: Journal article
URI: http://hdl.handle.net/1885/95375
Source: Journal of Stem Cell Research & Therapy
DOI: 10.4172/2157-7633.1000117

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