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An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3

Zochling, Jane; Newell, Felicity; Charlesworth, Jac C; Leo, Paul; Stankovich, Jim; Cortes, Adrian; Zhou, Yuan; Stevens, Wendy; Sahhar, Joanne; Roddy, Janet; Nash, Peter; Tymms, Kathleen; Rischmueller, Maureen; Lester, Sue; Proudman, Susanna; Brown, Matthew A


INTRODUCTION The aim of the study was to interrogate the genetic architecture and autoimmune pleiotropy of scleroderma susceptibility in the Australian population. METHODS We genotyped individuals from a well-characterized cohort of Australian scleroderma patients with the Immunochip, a custom array enriched for single nucleotide polymorphisms (SNPs) at immune loci. Controls were taken from the 1958 British Birth Cohort. After data cleaning and adjusting for population stratification the final...[Show more]

CollectionsANU Research Publications
Date published: 2014-10-21
Type: Journal article
Source: Arthritis research & therapy
DOI: 10.1186/s13075-014-0438-8


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