Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder
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Christensen, Helen; Guastella, Adam J; Mackinnon, Andrew J; Griffiths, Kathleen M; Eagleson, Claire; Batterham, Philip; Kalia, Kanupriya; Kenardy, Justin; Bennett, Kylie; Hickie, Ian B
Description
BACKGROUND Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing symptoms of anxiety and stress for post traumatic stress disorder (PTSD), panic disorder, social phobia and depression. However, to date, there is little evidence for the effectiveness of e-health applications in adult GAD. There are no studies which have directly compared...[Show more]
dc.contributor.author | Christensen, Helen | |
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dc.contributor.author | Guastella, Adam J | |
dc.contributor.author | Mackinnon, Andrew J | |
dc.contributor.author | Griffiths, Kathleen M | |
dc.contributor.author | Eagleson, Claire | |
dc.contributor.author | Batterham, Philip | |
dc.contributor.author | Kalia, Kanupriya | |
dc.contributor.author | Kenardy, Justin | |
dc.contributor.author | Bennett, Kylie | |
dc.contributor.author | Hickie, Ian B | |
dc.date.accessioned | 2016-01-13T00:48:32Z | |
dc.date.available | 2016-01-13T00:48:32Z | |
dc.identifier.issn | 1745-6215 | |
dc.identifier.uri | http://hdl.handle.net/1885/95366 | |
dc.description.abstract | BACKGROUND Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing symptoms of anxiety and stress for post traumatic stress disorder (PTSD), panic disorder, social phobia and depression. However, to date, there is little evidence for the effectiveness of e-health applications in adult GAD. There are no studies which have directly compared e-health applications with recognised evidence-based medication. This study aims to determine the effectiveness of a web-based program for treating GAD relative to sertraline and attention placebo. METHODS/DESIGN 120 community-dwelling participants, aged 18-30 years with a clinical diagnosis of GAD will be recruited from the Australian Electoral Roll. They will be randomly allocated to one of three conditions: (i) an online treatment program for GAD, E-couch (ii) pharmacological treatment with a selective serotonin re-uptake inhibitor (SSRI), sertraline (a fixed-flexible dose of 25-100 mg/day) or (iii) an attention control placebo, HealthWatch. The treatment program will be completed over a 10 week period with a 12 month follow-up. DISCUSSION As of February 2010, there were no registered trials evaluating the effectiveness of an e-health application for GAD for young adults. Similarly to date, this will be the first trial to compare an e-health intervention with a pharmacological treatment. TRIAL REGISTRATION Current Controlled Trials ISRCTN76298775. | |
dc.description.sponsorship | NHMRC Fellowship 525411 to Helen Christensen. NHMRC Fellowship 525413 to Kathleen Griffiths. NHMRC Fellowship 464914 to Ian Hickie. NHMRC Project Grant 525419. NHMRC Capacity Building Grant 418020 supporting Philip Batterham. | |
dc.publisher | BioMed Central | |
dc.rights | © 2010 Christensen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |
dc.source | Trials | |
dc.subject | adolescent | |
dc.subject | adult | |
dc.subject | anti-anxiety agents | |
dc.subject | anxiety disorders | |
dc.subject | australia | |
dc.subject | female | |
dc.subject | humans | |
dc.subject | male | |
dc.subject | placebo effect | |
dc.subject | research design | |
dc.subject | sertraline | |
dc.subject | time factors | |
dc.subject | treatment outcome | |
dc.subject | young adult | |
dc.subject | cognitive therapy | |
dc.subject | internet | |
dc.title | Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 11 | |
dc.date.issued | 2010-04-30 | |
local.identifier.absfor | 110319 | |
local.identifier.ariespublication | f2965xPUB311 | |
local.publisher.url | http://www.biomedcentral.com/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Christensen, Helen, College of Medicine, Biology and Environment, CMBE Research School of Population Health, National Institute for Mental Health Research, The Australian National University | |
local.contributor.affiliation | Guastella, Adam, University of Sydney, Australia | |
local.contributor.affiliation | Mackinnon, Andrew, University of Melbourne, Australia | |
local.contributor.affiliation | Griffiths, Kathleen, College of Medicine, Biology and Environment, CMBE Research School of Population Health, National Institute for Mental Health Research, The Australian National University | |
local.contributor.affiliation | Eagleson, Claire, University of Sydney, Australia | |
local.contributor.affiliation | Batterham, Philip, College of Medicine, Biology and Environment, CMBE Research School of Population Health, National Institute for Mental Health Research, The Australian National University | |
local.contributor.affiliation | Kalia , Kanupriya, College of Medicine, Biology and Environment, CMBE Research School of Population Health, National Institute for Mental Health Research, The Australian National University | |
local.contributor.affiliation | Kenardy, Justin, University of Queensland, Australia | |
local.contributor.affiliation | Bennett (previously Brittliffe), Kylie, College of Medicine, Biology and Environment, CMBE Research School of Population Health, National Institute for Mental Health Research, The Australian National University | |
local.contributor.affiliation | Hickie, Ian B, University of Sydney, Australia | |
dc.relation | http://purl.org/au-research/grants/nhmrc/525411 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/525413 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/464914 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/525419 | |
dc.relation | http://purl.org/au-research/grants/nhmrc/418020 | |
local.identifier.essn | 1745-6215 | |
local.bibliographicCitation.issue | 1 | |
local.bibliographicCitation.startpage | 48 | |
local.identifier.doi | 10.1186/1745-6215-11-48 | |
local.identifier.absseo | 920209 | |
dc.date.updated | 2016-02-24T08:27:12Z | |
local.identifier.scopusID | 2-s2.0-77953939868 | |
local.identifier.thomsonID | 000278334000001 | |
Collections | ANU Research Publications |
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