Perera, Polwattage MS; Jayamanna, Shaluka F; Hettiarachchi, Raja; Abeysinghe, Chandana; Karunatilake, Harindra; Dawson, Andrew H; Buckley, Nick A
BACKGROUND An estimated 2-3 million people are acutely poisoned by organophosphorus pesticides each year, mostly in the developing world. There is a pressing need for new affordable antidotes and clonidine has been shown to be effective in animal studies. Our aim was to determine the safety of clonidine given as an antidote in adult patients presenting with signs or symptoms of acute organophosphate ingestion. METHODS This study was a dose finding, open-label, multicentre, phase II trial. Forty...[Show more]
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