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A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance

Ohanian, Monique; Humphreys, David T.; Anderson, Elizabeth; Preiss, Thomas; Fatkin, Diane


BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Sequential cleavage of miRNA precursors results in a ~22 nucleotide duplex of which one strand, the mature miRNA, is typically loaded into the RNA-induced silencing complex (RISC) while the passenger strand is degraded. Very little is known about how genetic variation might affect miRNA biogenesis and function. RESULTS We re-sequenced the MIR1-1, MIR1-2, MIR133A1, MIR133A2, and MIR133B...[Show more]

CollectionsANU Research Publications
Date published: 2013-03-06
Type: Journal article
Source: BMC Genetics
DOI: 10.1186/1471-2156-14-18


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