Simultaneous alignment of short reads against multiple genomes
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Schneeberger, Korbinian; Hagmann, Jörg; Ossowski, Stephan; Warthmann, Norman; Gesing, Sandra; Kohlbacher, Oliver; Weigel, Detlef
Description
Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes (e.g., individuals of the same species) into a single graph structure. It constitutes the first approach for handling multiple references and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009-09-17 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/95312 |
Source: | Genome Biology |
DOI: | 10.1186/gb-2009-10-9-r98 |
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01_Schneeberger_Simultaneous_alignment_of_2009.pdf | Published Version | 196.64 kB | Adobe PDF | ![]() |
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