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Simultaneous alignment of short reads against multiple genomes

Schneeberger, Korbinian; Hagmann, Jörg; Ossowski, Stephan; Warthmann, Norman; Gesing, Sandra; Kohlbacher, Oliver; Weigel, Detlef


Genome resequencing with short reads generally relies on alignments against a single reference. GenomeMapper supports simultaneous mapping of short reads against multiple genomes by integrating related genomes (e.g., individuals of the same species) into a single graph structure. It constitutes the first approach for handling multiple references and introduces representations for alignments against complex structures. Demonstrated benefits include access to polymorphisms that cannot be...[Show more]

CollectionsANU Research Publications
Date published: 2009-09-17
Type: Journal article
Source: Genome Biology
DOI: 10.1186/gb-2009-10-9-r98


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