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Progenitor cells of the rod-free area centralis originate in the anterior dorsal optic vesicle

Shin, Sae; O'Brien, Keely


BACKGROUND Nervous system development is dependent on early regional specification to create functionally distinct tissues within an initially undifferentiated zone. Within the retina, photoreceptors are topographically organized with rod free area centrales faithfully generated at the centre of gaze. How does the developing eye regulate this placement? Conventional wisdom indicates that the distal tip of the growing optic vesicle (OV) gives rise to the area centralis/fovea. Ectopic expression...[Show more]

CollectionsANU Research Publications
Date published: 2009-11-25
Type: Journal article
Source: BMC Developmental Biology
DOI: 10.1186/1471-213X-9-57


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