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Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Culverhouse, Robert C; Bowes, Lucy; Breslau, Naomi; Nurnberger Jr, John I; Burmeister, Margit; Fergusson, David M; Munafò, Marcus; Saccone, Nancy L; Bierut, Laura J

Description

BACKGROUND Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions. METHODS/DESIGN...[Show more]

CollectionsANU Research Publications
Date published: 2013-11-12
Type: Journal article
URI: http://hdl.handle.net/1885/95289
Source: BMC Psychiatry
DOI: 10.1186/1471-244X-13-304

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