Adipose tissue has significant roles in whole body energy homeostasis, systemic insulin sensitivity, and lipid metabolism. Increased food intake, physical inactivity, and genetic predisposition lead to over-expansion of adipose tissues. Under constant energy surplus, adipocytes become hypertrophic and adipose tissues undergo hyperplasia. These tissue modifications lead to recruitment of preadipocytes and preadipocyte progenitors (mesenchymal stem cells) into adipogenic lineage, thereby...[Show more]
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