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Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning

Graca, Luis; Daley, Stephen; Fairchild, Paul J.; Cobbold, Stephen P.; Waldmann, Herman


BACKGROUND A major challenge in the application of marrow transplantation as a route to immunological tolerance of a transplanted organ is to achieve hematopoietic stem cell (HSC) engraftment with minimal myelosuppressive treatments. RESULTS We here describe a combined antibody protocol which can achieve long-term engraftment with clinically relevant doses of MHC-mismatched bone marrow, without the need for myelosuppressive drugs. Although not universally applicable in all strains, we achieved...[Show more]

CollectionsANU Research Publications
Date published: 2006-04-25
Type: Journal article
Source: BMC Immunology
DOI: 10.1186/1471-2172-7-9


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