Skip navigation
Skip navigation

Co-receptor and co-stimulation blockade for mixed chimerism and tolerance without myelosuppressive conditioning

Graca, Luis; Daley, Stephen; Fairchild, Paul J.; Cobbold, Stephen P.; Waldmann, Herman

Description

BACKGROUND A major challenge in the application of marrow transplantation as a route to immunological tolerance of a transplanted organ is to achieve hematopoietic stem cell (HSC) engraftment with minimal myelosuppressive treatments. RESULTS We here describe a combined antibody protocol which can achieve long-term engraftment with clinically relevant doses of MHC-mismatched bone marrow, without the need for myelosuppressive drugs. Although not universally applicable in all strains, we achieved...[Show more]

CollectionsANU Research Publications
Date published: 2006-04-25
Type: Journal article
URI: http://hdl.handle.net/1885/95286
Source: BMC Immunology
DOI: 10.1186/1471-2172-7-9

Download

File Description SizeFormat Image
01_Graca_Co-receptor_and_co-stimulation_2006.pdfPublished Version300.5 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  12 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator