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Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

Saunders, Neil FW; Brinkworth, Ross I.; Kemp, Bruce E; Kobe, Bostjan; Huber, Thomas


BACKGROUND We have previously described an approach to predicting the substrate specificity of serine-threonine protein kinases. The method, named Predikin, identifies key conserved substrate-determining residues in the kinase catalytic domain that contact the substrate in the region of the phosphorylation site and so determine the sequence surrounding the phosphorylation site. Predikin was implemented originally as a web application written in Javascript. RESULTS Here, we describe a new...[Show more]

CollectionsANU Research Publications
Date published: 2008-05-26
Type: Journal article
Source: BMC Bioinformatics
DOI: 10.1186/1471-2105-9-245


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