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Seroconversion and asymptomatic infections during oseltamivir prophylaxis against Influenza A H1N1 2009

Lee, Vernon J; Yap, Jonathan; Tay, Joshua K; Barr, Ian; Gao, Qiuhan; Ho, Hanley J; Tan, Boon; Kelly, Paul M; Tambyah, Paul A; Kelso, Anne; Chen, Mark I


BACKGROUND Anti-viral prophylaxis is used to prevent the transmission of influenza. We studied serological confirmation of 2009 Influenza A (H1N1) infections during oseltamivir prophylaxis and after cessation of prophylaxis. METHODS Between 22 Jun and 16 Jul 09, we performed a cohort study in 3 outbreaks in the Singapore military where post-exposure oseltamivir ring chemoprophylaxis (75 mg daily for 10 days) was administered. The entire cohort was screened by RT-PCR (with HA gene primers) using...[Show more]

CollectionsANU Research Publications
Date published: 2010-06-10
Type: Journal article
Source: BMC Infectious Diseases
DOI: 10.1186/1471-2334-10-164


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