Akkermans, Reinier P.; Berrevoets, Marvin A.; Smeele, Ivo J.; Lucas, Annelies E.; Thoonen, Bart P.; Grootens-Stekelenburg, Joke G.; Heijdra, Yvonne; van Weel, Chris; Schermer, Tjard R.
BACKGROUND Current COPD guidelines advocate a fixed < 0.70 FEV1/FVC cutpoint to define airflow obstruction. We compared rate of lung function decline in respiratory symptomatic 40+ subjects who were 'obstructive' or 'non-obstructive' according to the fixed and/or age and gender specific lower limit of normal (LLN) FEV1/FVC cutpoints. METHODS We studied 3,324 respiratory symptomatic subjects referred to primary care diagnostic centres for spirometry. The cohort was subdivided into four...[Show more]
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