A method to study the effect of bronchodilators on smoke retention in COPD patients: study protocol for a randomized controlled trial
BACKGROUND Chronic obstructive pulmonary disease (COPD) is a common disease, associated with cardiovascular disease. Many patients use (long-acting) bronchodilators, whilst they continue smoking alongside. We hypothesised an interaction between bronchodilators and smoking that enhances smoke exposure, and hence cardiovascular disease. In this paper, we report our study protocol that explores the fundamental interaction, i.e. smoke retention. METHOD The design consists of a double-blinded,...[Show more]
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