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Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic

Al Nadaf, Shafagh; Waters, Paul D.; Koina, Edda; Deakin, Janine E.; Jordan, Kristen S.; Graves, Jennifer A.


BACKGROUND: X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii). In marsupials, X inactivation is known to be paternal, incomplete and tissue-specific, and occurs in the absence of an XIST orthologue. RESULTS: We examined expression of X-borne genes...[Show more]

CollectionsANU Research Publications
Date published: 2010-12-23
Type: Journal article
Source: Genome Biology
DOI: 10.1186/gb-2010-11-12-r122


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