Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic
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Al Nadaf, Shafagh; Waters, Paul D.; Koina, Edda; Deakin, Janine E.; Jordan, Kristen S.; Graves, Jennifer A.
Description
BACKGROUND: X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii). In marsupials, X inactivation is known to be paternal, incomplete and tissue-specific, and occurs in the absence of an XIST orthologue. RESULTS: We examined expression of X-borne genes...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010-12-23 |
Type: | Journal article |
URI: | http://dx.doi.org/10.1186/gb-2010-11-12-r122 http://hdl.handle.net/1885/95201 |
Source: | Genome Biology |
DOI: | 10.1186/gb-2010-11-12-r122 |
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File | Description | Size | Format | Image |
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01_Al Nadaf_Activity Map of the Tammar 2010.pdf | 1.89 MB | Adobe PDF | ![]() |
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