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Deubiquitylating enzymes and disease

Singhal, Shweta; Taylor, Matthew C; Baker, Rohan


Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates. DUBs thus have the potential to regulate any UBIQ-mediated cellular process, the two best characterized being proteolysis and protein trafficking. Mammals contain some 80-90 DUBs in five different subfamilies, only a handful of which have been characterized with...[Show more]

CollectionsANU Research Publications
Date published: 2008-10-21
Type: Journal article
Source: BMC Biochemistry
DOI: 10.1186/1471-2091-9-S1-S3


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