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Duplicability of self-interacting human genes

Perez-Bercoff, Asa; Makino, Takashi; McLysaght, Aoife

Description

BACKGROUND There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model proposes that the evolution of new protein-protein interactions and protein complexes proceeds through the duplication of self-interacting genes. This model is supported by data from yeast. We examined the relationship between gene duplication and self-interaction in the human...[Show more]

dc.contributor.authorPerez-Bercoff, Asa
dc.contributor.authorMakino, Takashi
dc.contributor.authorMcLysaght, Aoife
dc.date.accessioned2015-12-23T03:22:07Z
dc.date.available2015-12-23T03:22:07Z
dc.identifier.issn1471-2148
dc.identifier.urihttp://hdl.handle.net/1885/95184
dc.description.abstractBACKGROUND There is increasing interest in the evolution of protein-protein interactions because this should ultimately be informative of the patterns of evolution of new protein functions within the cell. One model proposes that the evolution of new protein-protein interactions and protein complexes proceeds through the duplication of self-interacting genes. This model is supported by data from yeast. We examined the relationship between gene duplication and self-interaction in the human genome. RESULTS We investigated the patterns of self-interaction and duplication among 34808 interactions encoded by 8881 human genes, and show that self-interacting proteins are encoded by genes with higher duplicability than genes whose proteins lack this type of interaction. We show that this result is robust against the system used to define duplicate genes. Finally we compared the presence of self-interactions amongst proteins whose genes have duplicated either through whole-genome duplication (WGD) or small-scale duplication (SSD), and show that the former tend to have more interactions in general. After controlling for age differences between the two sets of duplicates this result can be explained by the time since the gene duplication. CONCLUSIONS Genes encoding self-interacting proteins tend to have higher duplicability than proteins lacking self-interactions. Moreover these duplicate genes have more often arisen through whole-genome rather than small-scale duplication. Finally, self-interacting WGD genes tend to have more interaction partners in general in the PIN, which can be explained by their overall greater age. This work adds to our growing knowledge of the importance of contextual factors in gene duplicability.
dc.description.sponsorshipAt the time of publication the author Pérez-Bercoff was affiliated with Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin.
dc.publisherBioMed Central
dc.rights© Pérez-Bercoff et al. 2010 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.sourceBMC Evolutionary Biology
dc.subjectanimals
dc.subjectcomparative genomic hybridization
dc.subjectdatabases, genetic
dc.subjecthumans
dc.subjectmice
dc.subjectprotein interaction mapping
dc.subjectsequence analysis, dna
dc.subjectevolution, molecular
dc.subjectgene duplication
dc.subjectgenome, human
dc.subjectmodels, genetic
dc.titleDuplicability of self-interacting human genes
dc.typeJournal article
local.description.notesImported from ARIES.
local.identifier.citationvolume10
dc.date.issued2010-05-28
local.identifier.absfor060408
local.identifier.ariespublicationu3526593xPUB36
local.publisher.urlhttp://www.biomedcentral.com/
local.type.statusPublished Version
local.contributor.affiliationPerez-Bercoff, Asa, College of Medicine, Biology and Environment, CMBE John Curtin School of Medical Research, Genome Sciences, The Australian National University
local.contributor.affiliationMakino, T, Smurfit Institute of Genetics, Trinity College, , Ireland
local.contributor.affiliationMcLysaght, A, Smurfit Institute of Genetics, Trinity College,, Ireland
local.identifier.essn1471-2148
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage160
local.identifier.doi10.1186/1471-2148-10-160
dc.date.updated2016-02-24T10:16:49Z
local.identifier.scopusID2-s2.0-77952740223
CollectionsANU Research Publications

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