Gill, Jasmita; Kumar, Anuj; Yogavel, Manickam; Belrhali, Hassan; Jain, SK; Rug, Melanie; Brown, Monica; Maier, Alexander G; Sharma, Amit
BACKGROUND Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes. NAPs participate in the assembly and disassembly of nucleosomes thus contributing to chromatin structure organization. The human malaria parasite Plasmodium falciparum contains two nucleosome assembly proteins termed PfNapL and PfNapS. METHODS Three-dimensional crystal structure of PfNapS has been determined and analysed. Gene knockout and...[Show more]
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