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Plasticity of DNA methylation in mouse T cell activation and differentiation

Li, Yan; Chen, Guobing; Ma, Lina; Ohms, Stephen J; Sun, Chao; Shannon, M Frances; Fan, Jun Y


BACKGROUND Circulating CD4+ T helper cells are activated through interactions with antigen presenting cells and undergo differentiation into specific T helper cell subsets depending on the type of antigen encountered. In addition, the relative composition of the circulating CD4+ T cell population changes as animals mature with an increased percentage of the population being memory/effector type cells. RESULTS Here, we report on the highly plastic nature of DNA methylation at the genome-wide...[Show more]

CollectionsANU Research Publications
Date published: 2012-05-29
Type: Journal article
Source: BMC Molecular Biology
DOI: 10.1186/1471-2199-13-16


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