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Congenital leptin deficiency and thyroid function

Paz-Filho, Gilberto; Delibasi, Tuncay; Erol, Halil K; Wong, Ma-Li; Licinio, Julio

Description

Thyroid function is closely related to leptin's secretion by the adipose tissue. In states of leptin-deficiency, the circadian rhythm of TSH is altered, leading to central hypothyroidism in animal models. In humans, central hypothyroidism has also been described in rare cases of congenital leptin deficiency. However, the thyroid phenotype in these cases is heterogeneous, with the occurrence of central hypothyroidism in a minority of cases. Here we describe thyroid function in four...[Show more]

CollectionsANU Research Publications
Date published: 2009-11-04
Type: Journal article
URI: http://hdl.handle.net/1885/95170
Source: Thyroid Research
DOI: 10.1186/1756-6614-2-11

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