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670-nm light treatment reduces complement propagation following retinal degeneration

Rutar, Matt; Natoli, Riccardo; Albarracin, Rizalyn; Valter, Krisztina; Provis, Jan

Description

AIM Complement activation is associated with the pathogenesis of age-related macular degeneration (AMD). We aimed to investigate whether 670-nm light treatment reduces the propagation of complement in a light-induced model of atrophic AMD. METHODS Sprague-Dawley (SD) rats were pretreated with 9 J/cm(2) 670-nm light for 3 minutes daily over 5 days; other animals were sham treated. Animals were exposed to white light (1,000 lux) for 24 h, after which animals were kept in dim light (5 lux) for 7...[Show more]

CollectionsANU Research Publications
Date published: 2012-11-26
Type: Journal article
URI: http://hdl.handle.net/1885/95114
Source: Journal of Neuroinflammation
DOI: 10.1186/1742-2094-9-257

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