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Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

Rutar, Matt; Natoli, Riccardo; Provis, Jan M


BACKGROUND The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related macular degeneration (AMD). We investigated the role of Müller cell-derived chemokine (C-C motif) ligand (Ccl)2 expression on monocyte/microglia infiltration and photoreceptor death in light-mediated retinal degeneration, using targeted small interfering (si)RNA. METHODS Adult Sprague-Dawley rats were injected intravitreally with 1...[Show more]

CollectionsANU Research Publications
Date published: 2012-09-19
Type: Journal article
Source: Journal of Neuroinflammation
DOI: 10.1186/1742-2094-9-221


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