Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration
BACKGROUND The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related macular degeneration (AMD). We investigated the role of Müller cell-derived chemokine (C-C motif) ligand (Ccl)2 expression on monocyte/microglia infiltration and photoreceptor death in light-mediated retinal degeneration, using targeted small interfering (si)RNA. METHODS Adult Sprague-Dawley rats were injected intravitreally with 1...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Neuroinflammation|
|01_Rutar_Small_interfering_RNA-mediated_2012.pdf||Published Version||1.82 MB||Adobe PDF|
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