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Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency

Russell, Tiffany Ann

Description

Herpes Simplex Virus (HSV) type I causes cold sores but is also associated with severe outcomes such as encephalitis and blindness. The primary lytic HSV-1 infection in the skin and peripheral nervous system (PNS) is limited to around a week, but latent virus persists in neurons, from which it can reactivate periodically. A black and white view of lytic versus latent infection persists in the HSV literature. Somewhat paradoxically, there remains concern that ‘true’ latent infection cannot be...[Show more]

CollectionsOpen Access Theses
Date published: 2015-08
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/95063

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