Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
Herpes Simplex Virus (HSV) type I causes cold sores but is also associated with severe outcomes such as encephalitis and blindness. The primary lytic HSV-1 infection in the skin and peripheral nervous system (PNS) is limited to around a week, but latent virus persists in neurons, from which it can reactivate periodically. A black and white view of lytic versus latent infection persists in the HSV literature. Somewhat paradoxically, there remains concern that ‘true’ latent infection cannot be...[Show more]
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