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Cooperation of decay-accelerating factor and membrane cofactor protein in regulating survival of human cervical cancer cells

Gao, Ling-Juan; Guo, Shu-Yu; Cai, You-Qun; Gu, Ping-Qing; Su, Ya-Juan; Gong, Hui; Liu, Yun; Chen, Chen


BACKGROUND Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts the action of complement at critical stages of the cascade reaction. The cooperative effect of DAF and MCP on the survival of human cervical cancer cell (ME180) has not been demonstrated. METHODS In this study we applied, for the first time, short hairpin RNA (shRNA) to knock down the expression of the DAF and MCP with the...[Show more]

CollectionsANU Research Publications
Date published: 2009-10-30
Type: Journal article
Source: BMC Cancer
DOI: 10.1186/1471-2407-9-384


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