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Chemokine-mediated inflammation in the degenerating retina is coordinated by Müller cells, activated microglia, and retinal pigment epithelium

Rutar, Matt; Natoli, Riccardo; Chia, RX; Valter, Krisztina; Provis, Jan M


BACKGROUND Monocyte infiltration is involved in the pathogenesis of many retinal degenerative conditions. This process traditionally depends on local expression of chemokines, though the roles of many of these in the degenerating retina are unclear. Here, we investigate expression and in situ localization of the broad chemokine response in a light-induced model of retinal degeneration. METHODS Sprague-Dawley (SD) rats were exposed to 1,000 lux light damage (LD) for up to 24 hrs. At time points...[Show more]

CollectionsANU Research Publications
Date published: 2015-01-17
Type: Journal article
Source: Journal of Neuroinflammation
DOI: 10.1186/s12974-014-0224-1


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