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Toll-Like Receptors and Cancer: MYD88 Mutation and Inflammation

Wang, James Q.; Jeelall, Yogesh S.; Ferguson, Laura L.; Horikawa, Keisuke

Description

Pattern recognition receptors (PRRs) expressed on immune cells are crucial for the early detection of invading pathogens, in initiating early innate immune response and in orchestrating the adaptive immune response. PRRs are activated by specific pathogen-associated molecular patterns that are present in pathogenic microbes or nucleic acids of viruses or bacteria. However, inappropriate activation of these PRRs, such as the Toll-like receptors (TLRs), due to genetic lesions or chronic...[Show more]

CollectionsANU Research Publications
Date published: 2014-07-31
Type: Journal article
URI: http://hdl.handle.net/1885/95033
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2014.00367

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