Biostatistical methodology to accommodate genotype by environment (G-E) interactions in planned breeding trials for animals and for plants (such as crop variety trials) is well-advanced. Incorporation of environmental effects into genetic models for human data is generally more problematic. For continuous traits, such as height, IQ, blood pressure and cholesterol level measurements (to name a few), there is a vast literature on approaches that can be traced back over 80 years. However, many of...[Show more]
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