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Modelling linkage and association, with evaluation of common sampling schemes

Wicks, J; Wilson, Susan

Description

The probability model of parental transmission (of a multiallelic marker) to affected offspring has been reparameterized in such a way as to distinguish the recombination fraction parameter from the association parameters. The advantage of this reparameterization is that statistical tests can be developed which disentangle linkage and association. It is shown that these tests perform well compared with a standard approach that is commonly used. Further, the simulated data (Problem 2) enable a...[Show more]

dc.contributor.authorWicks, J
dc.contributor.authorWilson, Susan
dc.date.accessioned2015-12-13T23:41:31Z
dc.date.available2015-12-13T23:41:31Z
dc.identifier.issn0741-0395
dc.identifier.urihttp://hdl.handle.net/1885/94942
dc.description.abstractThe probability model of parental transmission (of a multiallelic marker) to affected offspring has been reparameterized in such a way as to distinguish the recombination fraction parameter from the association parameters. The advantage of this reparameterization is that statistical tests can be developed which disentangle linkage and association. It is shown that these tests perform well compared with a standard approach that is commonly used. Further, the simulated data (Problem 2) enable a comparison to be made of the performance of these tests under different family sampling schemes.
dc.publisherWiley-Liss Inc
dc.sourceGenetic Epidemiology
dc.subjectKeywords: child parent relation; conference paper; genetic association; genetic linkage; intermethod comparison; mathematical model; maximum likelihood method; probability; simulation; Family; Humans; Likelihood Functions; Linkage (Genetics); Linkage Disequilibrium Ascertainment sampling schemes; Likelihood ratio tests; Transmission/disequilibrium test
dc.titleModelling linkage and association, with evaluation of common sampling schemes
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume17
dc.date.issued1999
local.identifier.absfor010405 - Statistical Theory
local.identifier.ariespublicationMigratedxPub24655
local.type.statusPublished Version
local.contributor.affiliationWicks, J, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWilson, Susan, College of Physical and Mathematical Sciences, ANU
local.bibliographicCitation.issue1
local.bibliographicCitation.startpageS755
local.bibliographicCitation.lastpageS760
dc.date.updated2015-12-12T09:32:50Z
local.identifier.scopusID2-s2.0-0032735662
CollectionsANU Research Publications

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