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Immunohistochemistry of Omega Class Glutathione S-Transferase in Human Tissues

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Yin, Zhan-Li; Le Couteur, D; Board, Philip; Dahlstrom, Jane

Description

Omega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal...[Show more]

dc.contributor.authorYin, Zhan-Li
dc.contributor.authorLe Couteur, D
dc.contributor.authorBoard, Philip
dc.contributor.authorDahlstrom, Jane
dc.date.accessioned2015-12-13T23:41:08Z
dc.identifier.issn0022-1554
dc.identifier.urihttp://hdl.handle.net/1885/94763
dc.description.abstractOmega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal myocytes, hepatocytes, biliary epithelium, ductal epithelium of the pancreas, Hoffbauer cells of the placenta, and follicular and C-cells of the thyroid. These observations and the known activity of GSTO1-1 suggest biological functions that are not shared with other GSTs.
dc.publisherHistochemical Society
dc.sourceJournal of Histochemistry and Cytochemistry
dc.subjectKeywords: glutathione transferase; article; cellular distribution; enzyme localization; glia cell; heart muscle cell; human; human tissue; immunohistochemistry; myoepithelium cell; neurosecretory cell; pancreas duct; placenta; priority journal; protein expression; Glutathione transferase; GSTO; Immunohistochemistry; Omega
dc.titleImmunohistochemistry of Omega Class Glutathione S-Transferase in Human Tissues
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume49
dc.date.issued2001
local.identifier.absfor060107 - Enzymes
local.identifier.ariespublicationMigratedxPub24437
local.type.statusPublished Version
local.contributor.affiliationYin, Zhan-Li, University of Sydney
local.contributor.affiliationDahlstrom, Jane, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLe Couteur, D, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBoard, Philip, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage983
local.bibliographicCitation.lastpage987
dc.date.updated2015-12-12T09:31:26Z
local.identifier.scopusID2-s2.0-0034912499
CollectionsANU Research Publications

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