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Mass Spectral Characterization of Dichloroacetic Acid-Modified Human Glutathione Transferase Zeta

Anderson, Wayne; Liebler, Daniel; Board, Philip; Anders, Michael

Description

Glutathione transferase zeta (GSTZ1-1) is widely expressed in eukaryotic species, and four human allelic variants of hGSTZ1-1 have been described. GSTZ1-1 catalyzes the cis-trans isomerization of maleylacetoacetate to fumarylacetoacetate and the biotransformation of a range of α-haloalkanoic acids. GSTZ1-1-catalyzed biotransformation of fluorine-lacking α,α-diha-loalkanoic acids, including dichloroacetic acid (DCA), results in the mechanism-based inactivation and covalent modification of the...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/94700
Source: Chemical Research in Toxicology
DOI: 10.1021/tx025553x

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