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Macrophages and nitric oxide as the possible cellular and molecular basis for strain and gender differences in susceptibility to autoimmune central nervous system inflammation

Staykova, Maria; Cowden, William; Willenborg, D


PVG rats are resistant to actively induced experimental autoimmune encephalomyelitis (EAE) and this appears to be directly related to high and sustained systemic levels of reactive nitrogen intermediates (RNI) following sensitization for EAE when compared to the highly susceptable Lewis rat. An apparent cellular basis for the different EAE susceptibility between the two rat strains is described. Spleens of PVG rats have increased monocyte/macrophage numbers (NO producing cells) and lower...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2002.01072.x


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