Skip navigation
Skip navigation

Host systemic and local nitric oxide levels do not correlate with rejection of pig proislet xenografts in mice

Simeonovic, Charmaine; Cordery, D; van Leeuwen, Barbara; Popp, Sarah; Townsend, Michelle; Paule, M; Wilson, James Dennis; Cowden, William


The rejection of pig proislet xenografts in mice is a CD4 T cell-dependent process in which macrophages play an important role. To assess the potential for activated macrophages to act as effector cells in xenograft destruction, we have examined the relationship between proislet xenograft rejection, two principal markers of macrophage activation, transcription of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO), and their temporal relationship to intragraft cytokine...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Xenotransplantation
DOI: 10.1034/j.1399-3089.2002.01024.x


There are no files associated with this item.

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator