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Host systemic and local nitric oxide levels do not correlate with rejection of pig proislet xenografts in mice

Simeonovic, Charmaine; Cordery, D; van Leeuwen, Barbara; Popp, Sarah; Townsend, Michelle; Paule, M; Wilson, James Dennis; Cowden, William

Description

The rejection of pig proislet xenografts in mice is a CD4 T cell-dependent process in which macrophages play an important role. To assess the potential for activated macrophages to act as effector cells in xenograft destruction, we have examined the relationship between proislet xenograft rejection, two principal markers of macrophage activation, transcription of inducible nitric oxide synthase (iNOS) and production of nitric oxide (NO), and their temporal relationship to intragraft cytokine...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/94641
Source: Xenotransplantation
DOI: 10.1034/j.1399-3089.2002.01024.x

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