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Successful boosting of a DNA measles immunization with an oral plant-derived measles virus vaccine

Webster, Diane; Cooney, Michelle; Huang, Zhongjun; Drew, Damian; Ramshaw, Ian; Dry, Ian B; Strugnell, R; Martin, Jenny; Wendler, E


Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.76.15.7910-7912.2002


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