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Novel approaches for identifying genes regulating lymphocyte development and function

Loy, A; Goodnow, Christopher


The draft sequence of the human and mouse genomes provides an unparalleled opportunity for understanding the genetic control of immune-cell development. Strategies can begin with a gene sequence and pursue a putative immune-system function by employing mRNA-expression profiling or creating gene knockouts in embryonic stem cells. The latter can be produced by utilising the Cre/Lox system, a tetracycline operon, a gene-trap method or chemical mutagenesis. Alternatively, mutant phenotypes (derived...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Current Opinion in Immunology
DOI: 10.1016/S0952-7915(02)00331-X


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