Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kB2 in regulating circulating B cell numbers
The number of circulating follicular B lymphocytes is normally kept within a precise range despite their dispersion through the body and daily overproduction of precursors in the bone marrow. By establishing a genome wide recessive mutation screen in C57BL/6 mice to identify critical components of immune system regulation, we identified a mutant strain with selective deficiency in recirculating B cells but not immature or peritoneal B1 cells. Analysis of mixed bone marrow chimeras established...[Show more]
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|Source:||Journal of Experimental Medicine|
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