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Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kB2 in regulating circulating B cell numbers

Miosge, Lisa; Blasioli, Julie; Blery, Mathieu; Goodnow, Christopher

Description

The number of circulating follicular B lymphocytes is normally kept within a precise range despite their dispersion through the body and daily overproduction of precursors in the bone marrow. By establishing a genome wide recessive mutation screen in C57BL/6 mice to identify critical components of immune system regulation, we identified a mutant strain with selective deficiency in recirculating B cells but not immature or peritoneal B1 cells. Analysis of mixed bone marrow chimeras established...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/94596
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20020959

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