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Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory

Martin, Stephen; Goodnow, Christopher

Description

The basis of immune memory leading to heightened secondary antibody responses is a longstanding unanswered issue. Here we show that a single irreversible molecular change in the B cell antigen receptor, which is brought about by immunoglobulin M (IgM) to

dc.contributor.authorMartin, Stephen
dc.contributor.authorGoodnow, Christopher
dc.date.accessioned2015-12-13T23:40:44Z
dc.identifier.issn1529-2908
dc.identifier.urihttp://hdl.handle.net/1885/94594
dc.description.abstractThe basis of immune memory leading to heightened secondary antibody responses is a longstanding unanswered issue. Here we show that a single irreversible molecular change in the B cell antigen receptor, which is brought about by immunoglobulin M (IgM) to
dc.publisherNature Publishing Group
dc.sourceNature Immunology
dc.subjectKeywords: B lymphocyte receptor; immunoglobulin G; immunoglobulin M; animal cell; animal experiment; animal tissue; antibody response; antigen specificity; article; B lymphocyte; cell count; controlled study; immunological memory; in vivo study; lymphocyte prolifer
dc.titleBurst-enhancing role of the IgG membrane tail as a molecular determinant of memory
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume3
dc.date.issued2002
local.identifier.absfor110303 - Clinical Microbiology
local.identifier.ariespublicationMigratedxPub24212
local.type.statusPublished Version
local.contributor.affiliationMartin, Stephen, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGoodnow, Christopher, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage182
local.bibliographicCitation.lastpage188
local.identifier.doi10.1038/ni752
dc.date.updated2015-12-12T09:30:13Z
local.identifier.scopusID2-s2.0-0036171910
CollectionsANU Research Publications

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