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Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes

Prasad, S; Goodnow, Christopher


Genes outside the MHC create a general susceptibility to autoimmunity in non-obese diabetic (NOD) mice. In this study, we describe marked differences in dendritic cell generation, in vitro, caused by non-MHC NOD genes. Bone marrow cells from NOD.H-2k mice cultured in vitro with GM-CSF and IL-4 generated a reduced yield of dendritic cells when compared to bone marrow cells from B10.H-2k mice. This was due to failure to pass through successive rounds of cell division and elevated levels of...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1046/j.1440-1711.2002.01074.x


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