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The sequence of Locusta RXR, homologous to Drosophila Utraspiracle, and its evolutionary implications

Hayward, David; Bastiani, J; Trueman, John; Riddiford, L; Ball, Eldon

Description

The cellular response to steroid hormones is mediated by nuclear receptors which act by regulating transcription. In Drosophila melanogaster, the receptor for the insect molting hormone, 20-hydroxyecdysone, is a heterodimer composed of the Ecdysone Receptor and Ultraspiracle (USP) proteins. The DNA binding domains of arthropod USPs and their vertebrate homologs, the retinoid X receptor (RXR) family, are highly conserved. The ligand binding domain sequences, however, divide into two distinct...[Show more]

dc.contributor.authorHayward, David
dc.contributor.authorBastiani, J
dc.contributor.authorTrueman, John
dc.contributor.authorRiddiford, L
dc.contributor.authorBall, Eldon
dc.date.accessioned2015-12-13T23:40:35Z
dc.identifier.issn0949-944X
dc.identifier.urihttp://hdl.handle.net/1885/94534
dc.description.abstractThe cellular response to steroid hormones is mediated by nuclear receptors which act by regulating transcription. In Drosophila melanogaster, the receptor for the insect molting hormone, 20-hydroxyecdysone, is a heterodimer composed of the Ecdysone Receptor and Ultraspiracle (USP) proteins. The DNA binding domains of arthropod USPs and their vertebrate homologs, the retinoid X receptor (RXR) family, are highly conserved. The ligand binding domain sequences, however, divide into two distinct groups. One group consists of sequences from members of the holometabolous higher insect orders Diptera and Lepidoptera, the other of sequences from vertebrates, a crab and a tick. We here report the sequence of an RXR/USP from the hemimetabolous orthopteran, Locusta migratoria. The locust RXR/USP ligand binding domain clearly falls in the vertebrate-crab-tick rather than the dipteran-lepidopteran group. The reason for the evolutionarily abrupt divergence of the dipteran and lepidopteran sequences is unknown, but it could be a change in the type of ligand bound or the loss of ligand altogether.
dc.publisherSpringer
dc.sourceDevelopment Genes and Evolution
dc.subjectKeywords: cell nucleus receptor; ecdysone; retinoid x receptor; article; crab; DNA binding; drosophila melanogaster; evolution; fly; genetic conservation; lepidoptera; ligand binding; locust; molecular evolution; nonhuman; priority journal; tick; Amino Acid Sequenc Ecdysone receptor; Locusta migratoria; Nuclear receptor; RXR; Ultraspiracle; Usp
dc.titleThe sequence of Locusta RXR, homologous to Drosophila Utraspiracle, and its evolutionary implications
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume209
dc.date.issued1999
local.identifier.absfor060403 - Developmental Genetics (incl. Sex Determination)
local.identifier.ariespublicationMigratedxPub24139
local.type.statusPublished Version
local.contributor.affiliationHayward, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBastiani, J, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTrueman, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRiddiford, L, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBall, Eldon, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage564
local.bibliographicCitation.lastpage571
local.identifier.doi10.1007/s004270050290
dc.date.updated2015-12-12T09:29:41Z
local.identifier.scopusID2-s2.0-0032826962
CollectionsANU Research Publications

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