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The sequence of Locusta RXR, homologous to Drosophila Utraspiracle, and its evolutionary implications

Hayward, David; Bastiani, J; Trueman, John; Riddiford, L; Ball, Eldon

Description

The cellular response to steroid hormones is mediated by nuclear receptors which act by regulating transcription. In Drosophila melanogaster, the receptor for the insect molting hormone, 20-hydroxyecdysone, is a heterodimer composed of the Ecdysone Receptor and Ultraspiracle (USP) proteins. The DNA binding domains of arthropod USPs and their vertebrate homologs, the retinoid X receptor (RXR) family, are highly conserved. The ligand binding domain sequences, however, divide into two distinct...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
URI: http://hdl.handle.net/1885/94534
Source: Development Genes and Evolution
DOI: 10.1007/s004270050290

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