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Evidence for phosphatidylinositol 4-kinase and actin involvement in the regulation of 125I-b-nerve growth factor retrograde axonal transport

Reynolds, Anna; Heydon, Katharina; Bartlett, Selena; Hendry, Ian


The signaling events regulating the retrograde axonal transport of neurotrophins are poorly understood, but a role for phosphatidylinositol kinases has been proposed. In this study, we used phenylarsine oxide (PAO) to examine the participation of phosphatidylinositol 4-kinases in nerve growth factor (NGF) retrograde axonal transport within sympathetic and sensory neurons. The retrograde transport of 125I-labeled βNGF was inhibited by PAO (0.5-2 nmol/eye), and this effect was diminished by...[Show more]

CollectionsANU Research Publications
Date published: 1999
Type: Journal article
Source: Journal of Neurochemistry
DOI: 10.1046/j.1471-4159.1999.0730087.x


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