Reynolds, Anna; Heydon, Katharina; Bartlett, Selena; Hendry, Ian
The signaling events regulating the retrograde axonal transport of neurotrophins are poorly understood, but a role for phosphatidylinositol kinases has been proposed. In this study, we used phenylarsine oxide (PAO) to examine the participation of phosphatidylinositol 4-kinases in nerve growth factor (NGF) retrograde axonal transport within sympathetic and sensory neurons. The retrograde transport of 125I-labeled βNGF was inhibited by PAO (0.5-2 nmol/eye), and this effect was diminished by...[Show more]
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