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Transport of cis- and trans-4-[�8F]fluoro-L-proline in F98 glioma cells

Langen, Karl-Josef; Muhlensiepen, Heinz; Schmieder, Sven; Hamacher, Kurt; Broer, Stefan; Borner, Anne R; Schneeweiss, Frank; Coenen, Heinz


The transport mechanisms of cis-4-[18F]fluoro-L-proline (cis-FPro) and trans-4-[18F]fluoro-L-proline (trans-FPro) were studied in F98 rat glioma cells in comparison to the natural parent [3H]-L-proline. Uptake rates of cis-FPro and trans-FPro in F98 glioma cells were 50-70% lower than those of [3H]-L-proline. The amino transport system A inhibitor MeAIB reduced the uptake of [3H]-L-proline by 30% and uptake of cis-FPro by 46% while uptake of trans-FPro was not significantly changed. BCH...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Nuclear Medicine and Biology
DOI: 10.1016/S0969-8051(02)00327-X


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