Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses
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MacLennan, Ian C M; Garcia De Vinuesa, Maria Carola
Description
The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.
dc.contributor.author | MacLennan, Ian C M | |
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dc.contributor.author | Garcia De Vinuesa, Maria Carola | |
dc.date.accessioned | 2015-12-13T23:39:53Z | |
dc.identifier.issn | 1074-7613 | |
dc.identifier.uri | http://hdl.handle.net/1885/94228 | |
dc.description.abstract | The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production. | |
dc.publisher | Cell Press | |
dc.source | Immunity | |
dc.subject | Keywords: APRIL protein; autoantibody; protein; protein BAFF; unclassified drug; amino acid sequence; antibody production; antibody response; B lymphocyte; cell activity; cell maturation; cell survival; dendrite; priority journal; regulatory mechanism; short survey | |
dc.title | Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 17 | |
dc.date.issued | 2002 | |
local.identifier.absfor | 110704 - Cellular Immunology | |
local.identifier.ariespublication | MigratedxPub23763 | |
local.type.status | Published Version | |
local.contributor.affiliation | MacLennan, Ian C M, University of Birmingham | |
local.contributor.affiliation | Garcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 235 | |
local.bibliographicCitation.lastpage | 238 | |
local.identifier.doi | 10.1016/S1074-7613(02)00398-9 | |
dc.date.updated | 2015-12-12T09:27:04Z | |
local.identifier.scopusID | 2-s2.0-0036753722 | |
Collections | ANU Research Publications |
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