Skip navigation
Skip navigation

Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

MacLennan, Ian C M; Garcia De Vinuesa, Maria Carola

Description

The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

dc.contributor.authorMacLennan, Ian C M
dc.contributor.authorGarcia De Vinuesa, Maria Carola
dc.date.accessioned2015-12-13T23:39:53Z
dc.identifier.issn1074-7613
dc.identifier.urihttp://hdl.handle.net/1885/94228
dc.description.abstractThe first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.
dc.publisherCell Press
dc.sourceImmunity
dc.subjectKeywords: APRIL protein; autoantibody; protein; protein BAFF; unclassified drug; amino acid sequence; antibody production; antibody response; B lymphocyte; cell activity; cell maturation; cell survival; dendrite; priority journal; regulatory mechanism; short survey
dc.titleDendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume17
dc.date.issued2002
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationMigratedxPub23763
local.type.statusPublished Version
local.contributor.affiliationMacLennan, Ian C M, University of Birmingham
local.contributor.affiliationGarcia De Vinuesa, Maria Carola, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage235
local.bibliographicCitation.lastpage238
local.identifier.doi10.1016/S1074-7613(02)00398-9
dc.date.updated2015-12-12T09:27:04Z
local.identifier.scopusID2-s2.0-0036753722
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_MacLennan_Dendritic_cells,_BAFF,_and_2002.pdf140.13 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator