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Dendritic cells, BAFF, and APRIL: Innate players in adaptive antibody responses

MacLennan, Ian C M; Garcia De Vinuesa, Maria Carola


The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Immunity
DOI: 10.1016/S1074-7613(02)00398-9


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