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Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ions

Broer, Angelika; Albers, Alexandra; Setiawan, Iwan; Edwards, Robert; Chaudhry, Farrukh; Lang, Florian; Wagner, Carsten; Broer, Stefan

Description

The glutamine transporter SN1 has recently been identified as one of the major glutamine transporters in hepatocytes and brain astrocytes. It appears to be the molecular correlate of system N amino acid transport. Two different transport mechanisms have been proposed for this transporter. These are an electroneutral mechanism, in which glutamine uptake is coupled to an exchange of 1Na+ and 1H+, or an electrogenic mechanism coupled to the exchange of 2Na+ against 1H+. This study was performed to...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
URI: http://hdl.handle.net/1885/94200
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2001.013303

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