Broer, Angelika; Albers, Alexandra; Setiawan, Iwan; Edwards, Robert; Chaudhry, Farrukh; Lang, Florian; Wagner, Carsten; Broer, Stefan
The glutamine transporter SN1 has recently been identified as one of the major glutamine transporters in hepatocytes and brain astrocytes. It appears to be the molecular correlate of system N amino acid transport. Two different transport mechanisms have been proposed for this transporter. These are an electroneutral mechanism, in which glutamine uptake is coupled to an exchange of 1Na+ and 1H+, or an electrogenic mechanism coupled to the exchange of 2Na+ against 1H+. This study was performed to...[Show more]
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