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Multi-component assembly of the bicyclic core associated with the tRNA synthetase inhibitors SB-203207 and SB-203208. Application to the synthesis of biologically active analogues

Banwell, Martin; Crasto, Curtis; Easton, Christopher; Karoli, Tomislav; March, Darren; Nairn, Michael; O'Hanlon, Peter; Oldham, Mark; Willis, Anthony; Yue, Weimin

Description

The ketone (±)-5, which embodies the bicyclic core associated with the title tRNA synthetase inhibitors 1 and 2, has been prepared via a three-component coupling reaction involving 2-(hydroxymethyl)cyclopent-2-enone (15), methylamine (6) and propiolamide

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
URI: http://hdl.handle.net/1885/94173
Source: Chemical Communications

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