Skip navigation
Skip navigation

Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: relevance to chromium genotoxicity

Pattison, David; Davies, Michael J; Levina, Aviva; Dixon, Nicholas; Lay, Peter


Catechols are found extensively in nature both as essential biomolecules and as the byproducts of normal oxidative damage of amino acids and proteins. They are also present in cigarette smoke and other atmospheric pollutants. Here, the interactions of reactive species generated in Cr(VI)/catechol(amine) mixtures with plasmid DNA have been investigated to model a potential route to Cr(VI)-induced genotoxicity. Reduction of Cr(VI) by 3,4-dihydroxyphenylalanine (DOPA) (1), dopamine (2), or...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Chemical Research in Toxicology
DOI: 10.1021/tx000229s


File Description SizeFormat Image
01_Pattison_Chromium(VI)_reduction_by_2001.pdf130.77 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator