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Interleukin-13 Mediates Airways Hyperreactivity through the IL-4 Receptor-Alpha Chain and STAT-6 Independently of IL-5 and Eotaxin

Yang, Ming; Hogan, Simon; Henry, Peter J.; Matthaei, Klaus; Mckenzie, Andrew N; Young, Ian; Rothenberg, Marc E; Foster, Paul S


Interleukin (IL)-13 is a central mediator of the processes underlying the induction of airways hyperreactivity (AHR) in the allergic lung. However, the mechanisms by which IL-13 induces AHR and the associated role of inflammatory infiltrates as effector cells has not been fully elucidated. In this investigation, we show that intratracheal administration of IL-13 induces AHR in the presence and absence of inflammation. The initial AHR response (peak, 6 to 24 h; preinflammatory phase [PIP]) was...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: American Journal of Respiratory Cell and Molecular Biology


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